2003年，广州中医药大学中药学院，学士；
2005年，中山大学药学院，硕士，导师：王冬梅；
2006-2007年，康化（上海）新药研发有限公司；
2011年，香港浸会大学化学系，博士，导师：蔡宗苇；
2010年5月-2010年8月，德国亥姆霍兹慕尼黑研究中心，交换生，导师：Philippe Schmitt-Kopplin；
2011-2012年，香港浸会大学化学系，博士后，合作导师：蔡宗苇；
2012年4月-2012年6月，德国亥姆霍兹慕尼黑研究中心，访问学者，合作导师：Philippe Schmitt-Kopplin；
2012-2014年，香港浸会大学化学系，研究助理教授，合作导师：蔡宗苇；
2014-2015年，香港浸会大学中医药学院，高级研究员，合作导师：卞兆祥；
2015年12月-2018年1月，上海交通大学医学院基础医学院副研究员、研究员；
2018年2月-8月，上海交通大学附属第六人民医院转化医学中心，研究员；
2018年10至今，伟德BETVlCTOR1946，教授。
2003, BSc, College of Chinese Medicine, Guangzhou University of Chinese Medicine;
2005, MSc, School of Pharmaceutical Sciences, Sun Yat-sen University;
2006-2007, PepTech (Shanghai) Pharmaceutical Co., Ltd;
2011, Ph. D., Department of Chemistry, Hong Kong Baptist University;
May 2010-Aug. 2010, Exchange Student, Helmholtz Zentrum München, Germany;
2011-2012, Postdoctoral Fellow, Department of Chemistry, Hong Kong Baptist University;
Apr. 2012-Jun. 2012, Visiting Scholar, Helmholtz Zentrum München, Germany;
2012-2014, Research Assistant Professor, Department of Chemistry, Hong Kong Baptist University;
2014-2015, Senior Research Associate, School of Chinese Medicine, Hong Kong Baptist University;
Dec. 2015-Jan. 2018, Associate Professor, Professor, College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine;
Feb. 2018-Aug. 2018, Professor, Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital;
Oct. 2018- Professor, School of Life Sciences, Xiamen University.

本课题组强调“通百艺，专一长”，整合数学、化学和生物医学等学科的知识和技术，开展代谢组学和细胞代谢研究。主要包括如下四个研究方向： 方向一：整合信号通路、代谢组学和代谢流分析技术，研究肿瘤发生发展过程中的线粒体代谢重编程； 方向二：基于单细胞、亚细胞的代谢组学和代谢流组学大数据，分析肿瘤免疫微环境中的代谢波动； 方向三：以化学的视角认识代谢通路，运用先进质谱技术，以期鉴定细胞中新型化学反应，拓宽细胞代谢网络； 方向四：运用质谱技术开展药物代谢组学，分析药物在体内的代谢规律与疗效评估。 无论你的本科专业是数学、物理、计算机、化学、生物还是医学，只要有志于从事代谢研究，勇于突破学科壁垒，挑战代谢领域的前沿研究课题，都欢迎加盟。同时欢迎医药企业交流合作！

代表性论文(^# co-first author, ^* Corresponding author):

1. Sun M, Li L, Niu Y, Wang Y, Yan Q, Xie F, Qiao Y, Song J, Sun H, Li Z, Lai S, Chang H, Zhang H, Wang J, Yang C, Zhao H, Tan J, Li Y, Liu S, Lu B, Liu M, Kong G, Zhao Y, Zhang C, Lin SH^*, Luo C^*, Zhang S^*, Shan C^*. PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism. Acta Pharm Sin B. 2023 Jan;13(1):157-173.
2. Lin SH^*, Yang Z. Reply to Firneisz: "Rebound increase in circulating dipeptidyl peptidase-4 (DPP4) enzyme activity after acute Covid-19". Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2220329120.
3. Xu XQ, Xu T, Ji W, Wang C, Ren Y, Xiong X, Zhou X^*, Lin SH^*, Xu Y^*, Qiu Y^*. Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis. mBio. 2023 Feb 28;14(1):e0237022.
4. Liu P, Tang N, Meng C, Yin Y, Qiu X, Tan L, Sun Y, Song C, Liu W, Liao Y, Lin SH^*, Ding C^*. SLC1A3 facilitates Newcastle disease virus replication by regulating glutamine catabolism. Virulence. 2022 Dec;13(1):1407-1422.
5. Yang Z, Wu D, Lu S, Qiu Y, Hua Z, Tan F, Zhang C, Zhang L, Zhang D, Zhou X^*, Cai Z^*, Shang Y^*, Lin SH^*. Plasma metabolome and cytokine profile reveal glycylproline modulating antibody-fading in convalescent COVID-19 patients. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2117089119.
6. Fan X, Wang Y, Cai X, Shen Y, Xu T, Xu Y, Cheng J, Wang X, Zhang L^*, Dai J^*, Lin S^*, Liu J^*. CPT2 K79 Acetylation Regulates Platelet Lifespan. Blood Adv. 2022 Sep 13;6(17):4924-4935.
7. Liu Y, Cong Y, Niu Y, Yuan Y, Tan F, Lai Q, Hu Y, Hou B, Li J, Lin C, Zheng H, Dong J, Tang J, Chen Q, Brzostek J, Zhang X, Chen XL, Wang HR, Gascoigne NRJ, Xu B^*, Lin SH^*, Fu G^*. Themis is indispensable for IL-2 and IL-15 signaling in T cells. Sci Signal. 2022 Feb 15;15(721):eabi9983.
8. Yang Z, Yang D, Tan F, Wong CW, Yang JY, Zhou D^*, Cai Z^*, Lin SH^*. Multi-Omics Comparison of the Spontaneous Diabetes Mellitus and Diet-Induced Prediabetic Macaque Models. Front Pharmacol. 2021 Nov 22;12:784231.
9. Gong Y, Tang N, Liu P, Sun Y, Lu S, Liu W, Tan L, Song C, Qiu X, Liao Y, Yu S, Liu X, Lin SH^*, Ding C^*. Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells. Autophagy. 2022 Jul;18(7):1503-1521.
10. Shi Z, Gan G, Xu X, Zhang J, Yuan Y, Bi B, Gao X, Xu P, Zeng W, Li J, Ye Y, Zhou A, Zhang N, Liu W^*, Lin S^*, Mi J^*. Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1. J Hematol Oncol. 2021 Sep 25;14(1):153.
11. Lin Q, Rong L, Jia X, Li R, Yu B, Hu J, Luo X, Badea SR, Xu C, Fu G, Lai K, Lee MC, Zhang B, Gong H, Zhou N, Chen XL, Lin SH^*, Fu G^*, Huang JD^*. IFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella. Nat Commun. 2021; 12(1):2537.
12. Guo W, Li K, Sun B, Xu D, Tong L, Yin H, Liao Y, Song H, Wang T, Jing B, Hu M, Liu S, Kuang Y, Ling J, Li Q, Wu Y, Wang Q, Yao F, Zhou BP, Lin SH^*, Deng J^*. Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer. Cancer Res. 2021; 81(3):552-566.
13. Zhao Y, Shang Y, Ren Y, Bie Y, Qiu Y, Yuan Y, Zhao Y, Zou L^*, Lin SH^*, Zhou X^*. Omics study reveals abnormal alterations of breastmilk proteins and metabolites in puerperant women with COVID-19. Signal Transduct Target Ther. 2020; 5(1):247.
14. Wu D, Shu T, Yang X, Song JX, Zhang M, Yao C, Liu W, Huang M, Yu Y, Yang Q, Zhu T, Xu J, Mu J, Wang Y, Wang H, Tang T, Ren Y, Wu Y, Lin SH^*, Qiu Y^*, Zhang DY^*, Shang Y^*, Zhou X^*. Plasma Metabolomic and Lipidomic Alterations Associated with COVID-19. Natl Sci Rev. 2020; 7(7): 1157–1168.
15. Jin N, Bi A, Lan X, Xu J, Wang X, Liu Y, Wang T, Tang S, Zeng H, Chen Z, Tan M, Ai J, Xie H, Zhang T, Liu D, Huang R, Song Y, Leung EL, Yao X, Ding J, Geng M^*, Lin SH^*, Huang M^*. Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer. Nat Commun. 2019; 10(1):2701.
16. Li M, Lu Y, Li Y, Tong L, Gu XC, Meng J, Zhu Y, Wu L, Feng M, Tian N, Zhang P, Xu T, Lin SH^*, Tong X^*. Transketolase Deficiency Protects the Liver from DNA Damage by Increasing Levels of Ribose 5-Phosphate and Nucleotides. Cancer Res. 2019; 79(14):3689-3701.
17. Chen GQ, Gong RH, Yang DJ, Zhang G, Lu AP, Yan SC, Lin SH^*, Bian ZX^*. Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer. Cell Death Dis. 2017 May 11;8(5):e2789.

荣誉、奖励及参加学术团体的情况:

执教课程:
有机化学（使用教材：南京大学出版社，陆国元主编，第三版）