2010年,湖南师范大学生物科学专业,学士学位;
2015年,中南大学大学遗传学专业,博士学位;
2016-2022年,美国罗切斯特大学,博士后;
2022年,伟德BETVlCTOR1946,助理教授
B.S. 2010, Hunan Normal University, Biology;
Ph.D. 2015, Central South University, Genetics;
Postdoctoral Associate, University of Rochester, 2016-2022;
Assistant Professor, School of Life Sciences, Xiamen University, Since 2022
动物的神经系统如何编码本能行为,并根据环境变化适时调节自身行为反应和代谢水平是重要的科学问题。在相同环境下,不同性别的动物可能出现差异化的行为模式和代谢水平。本人及课题组利用秀丽线虫作为模式动物研究化学趋向行为和逃避行为可塑性的分子和神经机制,解析这些机制背后潜在的两性差异,并探索线虫体内各种代谢产物的变化规律及其对物种繁衍和环境适应的贡献。
How innate behaviors are programmed in the nervous system, as well as how animals adjust their behavioral response and metabolic level according to the changing environment remain important scientific questions. Animals with distinct sex states could respond to identical circumstances with different behavioral patterns and metabolic levels. We are trying to uncover sex-dimorphic molecular and neural mechanisms behind the plasticity of chemotaxis and avoidance in C. elegans, and we are also interested in understanding how variable metabolites contribute to C. elegans reproduction fitness and environmental adaptability.
代表性论文(# co-first author, * Corresponding author):
1. Luo J, Portman DS. Sex-specific, pdfr-1-dependent Modulation of Pheromone Avoidance by Food Abundance Enables Flexibility in C. elegans Foraging Behavior. Curr Biol, 2021 Oct 25;31(20):4449-4461.e4.
2. Zhou C, Luo J, He X, Zhou Q, He Y, Wang X, Ma L. The NALCN Channel Regulator UNC-80 Functions in a Subset of Interneurons to Regulate Caenorhabditis elegans Reversal Behavior. G3 (Bethesda) . 2020 Jan 7;10(1):199-210.
3. Kiontke KC, Herrera RA, Vuong E, Luo J, Schwarz EM, Fitch DHA, Portman DS. The Long Non-coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28. Dev Cell. 2019 May 20;49(4):542-555.e9.
4. Fagan KA, Luo J, Lagoy RC, Schroeder FC, Albrecht DR, Portman DS. A Single-neuron Chemosensory Switch Determines the Valence of a Sexually Dimorphic Sensory Behavior. Curr Biol. 2018 Mar 19;28(6):902-914.e5.
5. Luo J, Xu Z, Tan Z, Zhang Z, Ma L. Neuropeptide Receptors NPR-1 and NPR-2 Regulate Caenorhabditis elegans Avoidance Response to the Plant Stress Hormone Methyl Salicylate. Genetics. 2015 Feb;199(2):523-31.
6. Xu Z, Luo J, Li Y, Ma L. The BLI-3/TSP-15/DOXA-1 Dual Oxidase Complex is Required forIodide Toxicity in Caenorhabditis elegans. G3 (Bethesda) . 2014 Dec 4;5(2):195-203.
7. Gao X, Teng Y, Luo J, Huang L, Li M, Zhang Z, Ma YC, Ma L. The Survival Motor Neuron Gene smn-1 Interacts with the U2AF Large Subunit Gene uaf-1 to Regulate Caenorhabditis elegans Lifespan and Motor Functions. RNA Biol. 2014;11(9):1148-60.
8. Ma L, Gao X, Luo J, Huang L, Teng Y, Horvitz HR. The Caenorhabditis elegans Gene mfap-1 Encodes a Nuclear Protein that Affects Alternative Splicing. PLoS Genet. 2012;8(7):e1002827.
荣誉、奖励及参加学术团体的情况: