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郑燚明教授博导

邮  箱:ymzheng@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2010年,重庆大学生物工程专业,学士学位;
2013年,重庆大学生物医学工程专业,硕士学位;
2019年,美国佛罗里达州立大学生物医学专业,博士学位;
2020年,美国佛罗里达州立大学,博士后;
2020-2022年,美国贝勒医学院,博士后;
2022年,伟德BETVlCTOR1946,教授;
2022年,伟德国际官网登录入口南强青年拔尖A类人才;
2021年,国家高层次青年人才
B.S. 2010, Chongqing University, Bioengineering;
M.S. 2013, Chongqing University, Biomedical Engineering;
Ph.D. 2019, Florida State University, Biomedical Sciences;
Postdoctoral Fellow, 2020, Florida State University;
Postdoctoral Fellow, 2020-2022, Baylor College of Medicine;
Professor, 2022-Present, School of Life Sciences, Xiamen University

郑燚明教授,国家海外高层次青年人才。神经损伤疾病如脑中风和脊髓损伤是至今未解决的重大医学难题,神经细胞死亡是神经损伤和退行性疾病如老年痴呆症的主要病理学特征,及时清除坏死神经细胞对于控制神经炎症和帮助神经再生至关重要。课题组主要致力于神经系统损伤和疾病过程中的细胞吞噬和降解研究,前期工作发现神经系统除了小胶质细胞作为主要的吞噬细胞,微血管内皮细胞在神经系统疾病中具有此前未知的吞噬功能属性,在神经系统脱髓鞘疾病的发展过程中扮演重要角色,相关研究成果发表于《Nature Neuroscience》和《Nature Cell Biology》等国际权威期刊。课题组综合运用小鼠遗传学、细胞分子生物学和成像技术,研究1)血管细胞作为新型吞噬细胞在神经损伤病变中的作用和调控机制;2) 血管细胞和胶质细胞互作调控神经损伤病变的机制;3)细胞骨架重构等重要生物学过程在神经系统发育和疾病中的作用。欢迎加入我们的团队。

代表性论文(# co-first author, * Corresponding author):

1. T. Zhou#, Y. Zheng#*, L. Sun, S.R. Badea, Y. Jin, Y. Liu, A. Rolfe, H. Sun, X. Wang, Z. Cheng, Z. Huang, N. Zhao, X. Sun, J. Li, J. Fan, C. Lee, T. L. Megraw, W. Wu, G. Wang*, Y. Ren*. Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury. Nature Neurosciences. 2019. 22(3):421-435. (#co-first authors, *co-corresponding authors)
2. Y. Zheng*, R.A. Buchwalter, C. Zheng, E. Wight, J.V, Chen, T. L. Megraw*. A perinuclear microtubule organizing centre controls nuclear positioning and basement membrane secretion. Nature Cell Biology. 2020. 22(3):297-309. (*co-corresponding authors)
3. Y. Zheng#, V. Mennella#, S. Marks, J. Wildonger, E. Elnagdi, D. Agard, T.L. Megraw. The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes, but is not required for normal development, behavior, or DNA damage response in Drosophila. Mol Biol Cell. 2016. 27(11):1740-52. (#co-first authors)
4. Y. Zheng, J. Qiu, J. Hu, G. Wang. Concepts and hypothesis: Integrin cytoplasmic domain-associated protein-1 (icap-1) as a potential player in cerebral cavernous malformation. J Neurol. 2013, 260(1):10-9.
5. Mengqi Ma, Mythily Ganapathi, Yiming Zheng, Kai-Li Tan, Oguz Kanca , Kevin E. Bove, Norma Quintanilla, Sebnem O. Sag, Sehime G. Temel, Charles A. LeDuc, Amanda J. McPartland, Elaine M. Pereira, Yufeng Shen, Jacob Hagen, Christie P. Thomas, Nhu Thao Nguyen Galván, Xueyang Pan, Shenzhao Lu, Jill A. Rosenfeld, Daniel G. Calame…Hugo J. Bellen. Homozygous missense variants in YKT6 result in loss of function and are associated with developmental delay, with or without severe infantile liver disease and risk for hepatocellular carcinoma. Genetics in Medicine. 2024
6. Mengqi Ma, Xi Zhang, Yiming Zheng, Shenzhao Lu, Xueyang Pan, Xiao Mao, Hongling Pan, Hyung-Lok Chung, Hua Wang, Hong Guo, Hugo J Bellen. The fly homolog of SUPT16H, a gene associated with neurodevelopmental disorders, is required in a cell-autonomous fashion for cell survival. Hum Mol Genet. 2023;32(6):984-997
7. D. Sun#, Y. Zheng#, T. Yin, C. Tang, Q. Yu, G. Wang. Coronary drug-eluting stents: from design optimization to newer strategies. (review) J Biomed Mater Res A. 2014, 102(5):1625-40 (#co-first author).

荣誉、奖励及参加学术团体的情况:

1. Travel award, ASCB | EMBO meeting, San Diego, CA, 2018
2. Randolph L. Rill Outstanding Senior Graduate Student Award, Florida State University, 2018
3. 1st place in 3-minute thesis presentation, 2nd BMS Retreat, Florida State University, 2018
4. 1st prize for poster presentation at the 1st BMS Retreat, Florida State University, 2016
5. Grant recipient, the 17th Annual Bryan W. Robinson Neuroscience Foundation, Tallahassee, 2015
6. Randolph L. Rill Outstanding Junior Graduate Student Award, Florida State University, 2015