Title: Gut-liver axis calibrates intestinal stem cell fitness

Speaker: Chuan Wu, M.D., Ph.D.

Time: November 4, 2024 at 9:15 AM

Venue: Academic Report Hall, Yuejin Building

Introduction of the reporter:In 2016, Dr. Wu joined the faculty at Brigham and Women’s Hospital, Harvard Medical School as an Assistant Professor and then moved to NCI in 2017 as an Earl Stadtman Investigator, where he re-directed his research to understand intercellular regulation on mucosal barrier integrity. In 2024, Dr. Wu was appointed as a senior investigator at the NCI. Dr. Wu’s lab is utilizing interdisciplinary approaches to elucidate the crosstalk between the nervous system, microbial pathogens, and the immune system. Their findings on how intercellular communications modulate epithelial barrier function can potentially facilitate the discovery of novel therapeutic targets and approaches for Inflammatory Bowel Disease (IBD) and colon cancer. Throughout his career, Dr. Wu has published many peer-reviewed manuscripts and review articles. His studies of cellular and molecular machineries of cell-cell interactions for regulating intestinal barrier function will have broad implications across the fields of immunology, physiology, and neuroendocrinology. His research will shed light on novel therapeutic targets to treat both intestinal inflammation and extraintestinal manifestations.