Education

1986, B. Med., The Fourth Military Medical University;

1996, Ph.D., Shanghai Cancer Institute.

Professional Experience

1998-1999, Postdoctoral Fellow, Max-Planck Institute for Biochemistry, Germany;

2000-2004, Postdoctoral Fellow, University of California Irvine;

2004-2006, Senior Researcher, University of California Irvine;

2006-Present, Professor, Xiamen University School of Life Sciences;

2012-Present, Deputy Dean, Xiamen University School of Life Sciences.

Research Area

The canonical Wnt signaling pathway plays a central role in normal development and tumorigenesis. We are particularly interested in studying the roles of Wnt signaling components and regulators in tissue development, metabolism, and tumorigenesis under the normal and stress conditions. Our research projects touch on the knowledge frontiers of epigenetics and stem cell biology.

Selected Publications

1.Wang S, He T, Luo Y, Ren K, Shen H, Hou L, Wei Y, Fu T, Xie W, Wang P, Hu J, Zhu Y, Huang Z, Li Q, Li W, Guo H^*, Li B^*. SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice. Cell Death Differ. 2024 Oct 15. doi: 10.1038/s41418-024-01397-0. Online ahead of print. PMID: 39402212
2.Mo C, You W, Rao Y, Lin Z, Wang S, He T, Shen H, Li X^*, Zhang R^*, Li B^*. Epigenetic regulation of DNA repair gene program by Hippo/YAP1-TET1 axis mediates sorafenib resistance in HCC. Cell Mol Life Sci. 2024 Jul 5;81(1):284. doi: 10.1007/s00018-024-05296-y.
3.Lu R, Hong J, Fu T, Zhu Y, Tong R, Ai D, Wang S, Huang Q, Chen C, Zhang Z, Zhang R^*, Guo H^*, Li B^*. Loss of OVOL2 in Triple-Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics. Advanced Science (Weinh). 2024 Apr 16:e2308945. doi: 10.1002/advs.202308945. Online ahead of print. PMID: 38627980
4.Lin KF, Yao KH , Li X , Li QH, Guo XJ , You WX , Ren WJ, Bian Y, Guo JG , Sun Z, Zhang R , Yang XQ^* , Li ZY^* , Li BA^* . Rapid and sensitive detection of nucleic acids using an RAA-CRISPR/Cas12b one-pot detection assay (Rcod). Talanta. 2024 May 1:271:125616.
5.Ma H, Suleman M, Zhang F, Cao T, Wen S, Sun D, Chen L, Jiang B, Wang Y, Lin F, Wang J, Li B^*, Li Q^*. Aspirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival.  Advanced Science (Weinh). 2024 Mar;11(10):e2301476. doi: 10.1002/advs.202301476. Epub 2023 Dec 26.PMID: 38148593
6.Guo J, You W, Lin K, Li Q, Guo X, Wang S, Bian Y, Ren W, Zhang R, Wang Y, Li B^*. An extraction-free method for rapid detection of CYP2C19 ^* 2/3/17 polymorphisms in one tube using melting curve analysis. Biotechnol J. 2023 Nov;18(11):e2300207. doi: 10.1002/biot.202300207. Epub 2023 Aug 31.
7.Liu Y, He T, Li Z, Sun Z, Wang S, Shen H, Hou L, Li S, Wei Y, Zhuo B, Li S, Zhou C, Guo H, Zhang R, Li B^*. TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation. iScience. 2023 Oct 23;26(11):108312. doi: 10.1016/j.isci.2023.108312. eCollection 2023 Nov 17.
8.He, T^# , Wang, S^# ., Li S^# ., Shen, H^# ., Hou, L., Liu, Y., Wei Y., Xie, F., Zhang, Z., Zhao, Z., Mo, C., Guo, H., Huang, Q., Zhang, R^*., Shen, D^*., and Li, BA^*. Suppression of preadipocyte determination by Sox4 limits white adipocyte hyperplasia in obesity. iScience. 2023 Feb 28;26(4):106289. doi: 10.1016/j.isci.2023.106289. eCollection 2023 Apr 21.
9.Lin KF, Guo JG, Guo XJ, Li QH, Li X, Sun Z, Zhao ZH, Weng J, Wu JZ^*,  Zhang R^*,  Li BA^*. Fast and visual detection of nucleic acid using One-step RPA-CRISPR Detection (ORCD) System. Analytica Chimica Acta. 2023 Apr 1;1248:340938. doi: 10.1016/j.aca.2023.340938. Epub 2023 Feb 3.
10. Shen H^# , He T^# , Wang S^# , Hou L^# , Wei Y, Liu Y, Mo C, Zhao Z, You W, Guo H^*, Li B^*. SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex. Theranostics.  2022; 12(18):7699-7716. doi:10.7150/thno.77102
11.Sun ^# Z, Lin KF^# , Zhao ZH^# , Wang Y, Hong XX, Guo JG, Ruan QY, Lu LY, Li X, Zhang R^*, Yang CY^*, Li BA^*. An automated nucleic acid detection platform using digital microfluidics with an optimized Cas12a system. Sci China Chem. 2022;65(3):630-640. doi: 10.1007/s11426-021-1169-1. Epub 2022 Jan 25.
12.Zhang R^# , Geng GJ^# , Guo JG^# , Mi YJ, Zhu XL, Li N, Liu HM, Lin JF, Wang JW, Zhao G, Ye GZ, Li BA^*, Luo QC^*, Jiang J^*. An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer. Cell Commun Signal. 2022 Mar 28;20(1):40. doi: 10.1186/s12964-022-00845-z.
13.Zheng ZZ, Li DY, Du KM, Xu X, Wang NJ, Yuan ZY^*, Li BA^*. "HLA-10-SNP": A new qPCR-based system for rapid, effective, and accurate detection of 10 important SNPs in the HLA region. HLA. 2021 Nov;98(5):459-466. doi: 10.1111/tan.14396. Epub 2021 Sep 9.PMID: 34375029
14.Zhang R^# , Hong JJ^# , Yang Q, Ong CT, Li BA^*, Liou YC^*. Poly(ADP-ribosyl)ation of OVOL2 regulates aneuploidy and cell death in cancer cells. Oncogene. 2018 Dec 12. doi: 10.1038/s41388-018-0615-3.
15.Xie YY^# , Mo CL^# , Cai YH, Wang WJ, Hong XX, Zhang KK, Liu QF, Liu YJ, Hong JJ, He T, Zheng ZZ, Mo W, and Li BA^* . Pygo2 regulates adiposity and glucose homeostasis via β-Catenin-Axin2-GSK3β signaling pathway. Diabetes. 2018 Dec;67(12):2569-2584. doi: 10.2337/db18-0311.
16.Lin LY, Yang L, Zeng Q, Wang L, Chen ML, Zhao ZH, Ye GD, Luo QC, Lv PY, Guo QW, Li BA^*, Cai JC^*, Cai WY^*. Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer. Mol Cancer. 2018 Apr 24;17(1):84. doi: 10.1186/s12943-018-0834-9.
17.Cai W, Chen G, Luo Q, Liu J, Guo X, Zhang T, Ma F, Yuan L, Li BA^*, Cai J^*. PMP22 Regulates Self-Renewal and Chemoresistance of Gastric Cancer Cells. Mol Cancer Ther. 2017 Jun;16(6):1187-1198. doi: 10.1158/1535-7163.MCT-16-0750.
18.Zheng Z, Zhang P, He G, Liao K, Wang Z, Pan J, Du K, Du J, Li BA^*. Simultaneous detection of 45 fusion genes in leukemia by dual-color fluorescence real-time PCR. Int J Lab Hematol. 2017 Apr;39(2):175-184. doi: 10.1111/ijlh.12600. Epub 2017 Jan 30.
19.Cai WY, Lin LY, Hao H, Zhang SM, Ma F, Hong XX, Zhang H, Liu QF, Ye GD, Sun GB, Liu YJ, Li SN, Xie YY, Cai JC, and Li BA^*. YAP-TEAD and HNF4α repress reciprocally to regulate hepatocarcinogenesis. Hepatology. 2017 Apr;65(4):1206-1221.
20.Zhang ZM, Wu JF, Luo QC, Liu QF, Wu QW, Ye GD, She HQ^*, and Li BA^*. Pygo2 activates MDR1 expression and mediates chemoresistance in breast cancer via the Wnt/β-catenin pathway. Oncogene, 2016.09.08，35（36）：4787-4797
21.Ye GD, Sun GB, Jiao P, Chen C, Liu QF, Huang XL, Zhang R, Cai WY, Li SN, Wu JF, Liu YJ, Wu RS, Xie YY, Chan EC, Liou YC, and Li BA^*. OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and is Downregulated in Human Colorectal Tumors. Gastroenterology.  2016 Mar;150(3):659-671.
22.Yang M, Li SN, Anjum KM, Gui LX, Zhu SS, Liu J,  Chen JK, Liu QF, Ye GD, Wang WJ, Wu JF, Cai WY, Sun GB, Liu YJ, Liu RF, Zhang ZM,  Li BA^* .Double-Negative Feedback Loop Between Wnt/β-catenin Signaling and HNF4α Regulates Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma. J Cell Sci. 2013 Dec 15;126(Pt 24):5692-5703.
23.Cai WY, Wei TZ, Luo QC, Wu QW, Liu QF, Yang M, Ye GD, Wu JF, Chen YY, Sun GB, Liu YJ, Zhao WX, Zhang ZM, Li BA^*. Wnt/β-catenin pathway represses let-7 microRNAs expression via transactivation of Lin28 to augment breast cancer stem cell expansion. J Cell Sci. 2013, Jul 1;126(Pt 13): 2877-2889.
24. Li BA^*. A novel tumor suppressor miRNA miR-520e contributes to suppression of hepatoma. Acta Pharmacol Sin. 2012 Jan; 33(1):3-4.
25.Chen HZ, Liu QF, Li L, Wang WJ, Yao LM, Yang M, Liu B, Chen W, Zhan YY, Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA^*, Wu Q^*. The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling . GUT.2012; 61:714-724.
26. Chen J,  Luo Q,  Yuan Y,  Huang X, Cai W,  Li C, Wei T,  Zhang L, Yang  M, Liu Q, Ye G, Cheng P, Dai X  and Li BA^*. Pygo2 associates with MLL2 histone methyltransferase (HMT) and GCN5 histone acetyltransferase (HAT) complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion. Mol. Cell. Biol. 2010 Dec;30(24):5621-35.  
27. Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, Takemaru K, Millar S, Lee EY, Lewis MT, and  Li BA^*, Dai X^*,  Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol. 2009, 185,811-826.