Education

1999-2003, School of Life Sciences, Xiamen University, B.S.

2003-2006, Department of Biochemistry, Hong Kong University of Science and Technology, Ph.D.

2006-2009, School of Life Sciences, Xiamen University, Ph.D.

Professional Experience

2009-2012, School of Life Sciences, Xiamen University, Assistant Professor

2012-2018, School of Life Sciences, Xiamen University, Associate Professor

2018-now, School of Life Sciences, Xiamen University, Professor

Research Area

The regulatory mechanisms and functions of the hub proteins of metabolic regulation such as AIDA, AXIN1 and p53, and nutrient sensing pathways such as GSK3-TIP60-ULK axis under physiological or pathophysiological processes, including nutrient sensing, carbohydrate and lipid metabolism and the development of metabolic disorders such as obesity, diabetes and cancer.

Selected Publications (*Corresponding author, #co-first author)

1.Shi M(^#), Huang XY(^#), Ren XY, Wei XY, Ma Y, Lin ZZ, Liu DT, Song L, Zhao TJ, Li G, Yao L, Zhu M, Zhang C, Xie C, Wu Y, Wu HM, Fan LP, Ou J, Zhan YH, Lin SY^*, Lin SC^*. AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1. Nature Cell Biology 2021 23: 268-277.
2.Lin SY^*, Lin SC. SRC promotes lipogenesis: implications for obesity and breast cancer. Molecular & Cellular Oncology 2021 8: 1866975.
3.Song L(^#), Liu Z(^#), Hu HH, Yang Y, Li TY, Lin ZZ, Ye J, Chen J, Huang X, Liu DT, Zhou J, Shi Y, Zhao H, Xie C, Chen L, Song E, Lin SY, Lin SC^*. Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy. Nature Communications 2020 11: 5842.
4.Lin SY, Zhang CS, Lin SC(^*). Carbohydrates: Not All that Bad? Cell Metabolism 2018 28: 671-672.
5.Li TY(^#), Song L(^#), Sun Y(^#), Li J, Yi C, Lam SM, Xu D, Zhou L, Li X, Yang Y, Zhang CS, Xie C, Huang X, Shui G, Lin SY, Reue K, Lin SC(^*). Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nature Communications 2018 9: 1916.
6.Luo H(^#), Jiang M(^#), Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY(^*), Lin SC(^*). AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity. Cell Metabolism 2018 27: 843-853.
7.Sun Y(^#), Li TY(^#), Song L(^#), Zhang C, Li J, Lin ZZ, Lin SC, Lin SY(^*). Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury. Hepatology 2018 67: 2397-2413.
8.Li TY, Sun Y, Liang Y, Liu Q, Shi Y, Zhang CS, Zhang C, Song L, Zhang P, Zhang X, Li X, Chen T, Huang HY, He X, Wang Y, Wu YQ, Chen S, Jiang M, Chen C, Xie C, Yang JY, Lin Y, Zhao S, Ye Z, Lin SY, Chiu DT, Lin SC(^*). ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy. Molecular Cell 2016 62: 359-370.
9.Zheng LS(^#), Liu YT(^#), Chen L, Wang Y, Rui YN, Huang HZ, Lin SY, Wang J, Wang ZX, Lin SC, Wu JW(^*). Structure and mechanism of the unique C2 domain of Aida. FEBS J. 2014 281: 4622-4632.
10.Li TY, Lin SY, Lin SC(^*). Mechanism and physiological significance of growth factor-related autophagy. Physiology (Bethesda) 2013 28: 423-431.
11.Ruan K(^#), Ye F(^#), Li C(^#), Liou YC, Lin SC, Lin SY(^*). PLK1 Interacts and Phosphorylates Axin That Is Essential for Proper Centrosome Formation. PLoS One 2012 7: e49184.
12.Lin SY(^#), Li TY(^#), Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC(^*). Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy. Autophagy 2012 8: 1385-1386.
13.Lin SY(^#), Li TY(^#), Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC(^*). GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy. Science 2012 336: 477-481.
14.Li Q(^#), Lin S(^#), Wang X(^#), Lian G, Lu Z, Guo H, Ruan K, Wang Y, Ye Z, Han J, Lin SC(^*). Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nature Cell Biology 2009 11: 1128-1134.
15.Lin S (^#), Wang J, Ye Z, Ip NY, Lin SC(^*). CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5. FEBS Letters 2008 582: 1197-1202.
16.Rui Y(^#), Xu Z(^#), Xiong B(^#), Cao Y(^#), Lin S, Zhang M, Chan SC, Luo W, Han Y, Lu Z, Ye Z, Zhou HM, Han J, Meng A(^*), Lin SC(^*). A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Developmental Cell 2007 13: 268-282.
17.Rui Y(^#), Xu Z(^#), Lin S, Li Q, Rui H, Luo W, Zhou HM, Cheung PY, Wu Z, Ye Z, Li P, Han J, Lin SC(^*). Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO Journal 2004 23: 4583-4594.