Education

2003, BSc, College of Chinese Medicine, Guangzhou University of Chinese Medicine

2005, MSc, School of Pharmaceutical Sciences, Sun Yat-sen University

2011, Ph. D., Department of Chemistry, Hong Kong Baptist University

Professional Experience

2006-2007, PepTech (Shanghai) Pharmaceutical Co., Ltd.

2011-2012, Postdoctoral Fellow, Department of Chemistry, Hong Kong Baptist University

2012-2014, Research Assistant Professor, Department of Chemistry, Hong Kong Baptist University

2014-2015, Senior Research Associate, School of Chinese Medicine, Hong Kong Baptist University

Dec. 2015-Jan. 2018, Associate Professor, Professor, College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine

Feb. 2018-Aug. 2018, Professor, Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital

Oct. 2018-Professor, School of Life Sciences, Xiamen University

Research Area

Metabolomics: By employing state-of-the-art mass spectrometry and stable isotope (13C, 15N, 2H) atoms in the tracer molecules, we analyze the specific metabolic pathways. Based on mass isotopologue distribution, we will establish mathematical modeling to delineate the activity and dynamic changes of metabolic pathways for metabolic flux analysis in in vivo and vitro. In vivo, we mainly focus on metabolic cross-talks between tissues and circulation system; in vitro, we mainly focus on metabolic communications between immune cells and other types of cells as well as metabolic shuttling at subcellular level, such as malate-aspartate shuttle, citrate-pyruvate shuttle and glycerophosphate shuttle.

Cellular metabolism: In the past decades, the impacts of microenvironment on cancer metabolism are largely overlooked. By applying metabolic flux analysis in vivo, in combination with biochemistry and genetics, we will quantitatively explain the impact of environmental factors on metabolic reprogramming in tumors. In particular, we are developing novel mass spectrometric technologies and collaborating with oncologists and immunologists for a better understanding of precision modulation of immunometabolism within the tumor microenvironment. We are also interested in the research fields ranging from distribution of nutrient utilization and energy expenditure in metabolic biology to metabolomics of clinical cohorts in precision medicine.

Selected Publications

1. Sun M, Li L, Niu Y, Wang Y, Yan Q, Xie F, Qiao Y, Song J, Sun H, Li Z, Lai S, Chang H, Zhang H, Wang J, Yang C, Zhao H, Tan J, Li Y, Liu S, Lu B, Liu M, Kong G, Zhao Y, Zhang C, Lin SH^*, Luo C^*, Zhang S^*, Shan C^*. PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism. Acta Pharm Sin B. 2023 Jan;13(1):157-173.
2. Lin SH^*, Yang Z. Reply to Firneisz: "Rebound increase in circulating dipeptidyl peptidase-4 (DPP4) enzyme activity after acute Covid-19". Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2220329120.
3. Xu XQ, Xu T, Ji W, Wang C, Ren Y, Xiong X, Zhou X^*, Lin SH^*, Xu Y^*, Qiu Y^*. Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis. mBio. 2023 Feb 28;14(1):e0237022.
4. Liu P, Tang N, Meng C, Yin Y, Qiu X, Tan L, Sun Y, Song C, Liu W, Liao Y, Lin SH^*, Ding C^*. SLC1A3 facilitates Newcastle disease virus replication by regulating glutamine catabolism. Virulence. 2022 Dec;13(1):1407-1422.
5. Yang Z, Wu D, Lu S, Qiu Y, Hua Z, Tan F, Zhang C, Zhang L, Zhang D, Zhou X^*, Cai Z^*, Shang Y^*, Lin SH^*. Plasma metabolome and cytokine profile reveal glycylproline modulating antibody-fading in convalescent COVID-19 patients. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2117089119.
6. Fan X, Wang Y, Cai X, Shen Y, Xu T, Xu Y, Cheng J, Wang X, Zhang L^*, Dai J^*, Lin S^*, Liu J^*. CPT2 K79 Acetylation Regulates Platelet Lifespan. Blood Adv. 2022 Sep 13;6(17):4924-4935.
7. Liu Y, Cong Y, Niu Y, Yuan Y, Tan F, Lai Q, Hu Y, Hou B, Li J, Lin C, Zheng H, Dong J, Tang J, Chen Q, Brzostek J, Zhang X, Chen XL, Wang HR, Gascoigne NRJ, Xu B^*, Lin SH^*, Fu G^*. Themis is indispensable for IL-2 and IL-15 signaling in T cells. Sci Signal. 2022 Feb 15;15(721):eabi9983.
8. Yang Z, Yang D, Tan F, Wong CW, Yang JY, Zhou D^*, Cai Z^*, Lin SH^*. Multi-Omics Comparison of the Spontaneous Diabetes Mellitus and Diet-Induced Prediabetic Macaque Models. Front Pharmacol. 2021 Nov 22;12:784231.
9. Gong Y, Tang N, Liu P, Sun Y, Lu S, Liu W, Tan L, Song C, Qiu X, Liao Y, Yu S, Liu X, Lin SH^*, Ding C^*. Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells. Autophagy. 2022 Jul;18(7):1503-1521.
10. Shi Z, Gan G, Xu X, Zhang J, Yuan Y, Bi B, Gao X, Xu P, Zeng W, Li J, Ye Y, Zhou A, Zhang N, Liu W^*, Lin S^*, Mi J^*. Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1. J Hematol Oncol. 2021 Sep 25;14(1):153.
11. Lin Q, Rong L, Jia X, Li R, Yu B, Hu J, Luo X, Badea SR, Xu C, Fu G, Lai K, Lee MC, Zhang B, Gong H, Zhou N, Chen XL, Lin SH^*, Fu G^*, Huang JD^*. IFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella. Nat Commun. 2021; 12(1):2537.
12. Guo W, Li K, Sun B, Xu D, Tong L, Yin H, Liao Y, Song H, Wang T, Jing B, Hu M, Liu S, Kuang Y, Ling J, Li Q, Wu Y, Wang Q, Yao F, Zhou BP, Lin SH^*, Deng J^*. Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer. Cancer Res. 2021; 81(3):552-566.
13. Zhao Y, Shang Y, Ren Y, Bie Y, Qiu Y, Yuan Y, Zhao Y, Zou L^*, Lin SH^*, Zhou X^*. Omics study reveals abnormal alterations of breastmilk proteins and metabolites in puerperant women with COVID-19. Signal Transduct Target Ther. 2020; 5(1):247.
14. Wu D, Shu T, Yang X, Song JX, Zhang M, Yao C, Liu W, Huang M, Yu Y, Yang Q, Zhu T, Xu J, Mu J, Wang Y, Wang H, Tang T, Ren Y, Wu Y, Lin SH^*, Qiu Y^*, Zhang DY^*, Shang Y^*, Zhou X^*. Plasma Metabolomic and Lipidomic Alterations Associated with COVID-19. Natl Sci Rev. 2020; 7(7): 1157–1168.
15. Jin N, Bi A, Lan X, Xu J, Wang X, Liu Y, Wang T, Tang S, Zeng H, Chen Z, Tan M, Ai J, Xie H, Zhang T, Liu D, Huang R, Song Y, Leung EL, Yao X, Ding J, Geng M^*, Lin SH^*, Huang M^*. Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer. Nat Commun. 2019; 10(1):2701.
16. Li M, Lu Y, Li Y, Tong L, Gu XC, Meng J, Zhu Y, Wu L, Feng M, Tian N, Zhang P, Xu T, Lin SH^*, Tong X^*. Transketolase Deficiency Protects the Liver from DNA Damage by Increasing Levels of Ribose 5-Phosphate and Nucleotides. Cancer Res. 2019; 79(14):3689-3701.
17. Chen GQ, Gong RH, Yang DJ, Zhang G, Lu AP, Yan SC, Lin SH^*, Bian ZX^*. Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer. Cell Death Dis. 2017 May 11;8(5):e2789.