Education

1990, B.Sc., Northeast Normal University;

1993, M.Sc., Northeast Normal University;

1999, Ph.D., University of Vienna, Austria.

Professional Experience

1999-2002, Postdoctoral fellow sponsored by Alexander von Humboldt Research Fellowship at Henrich-Heine Duesseldorf University, Germany;

2002-2006, Postdoctoral fellow, University of Massachusetts Medical School, USA;

2006-Present, Professor, School of Life Sciences, Xiamen University.

Research Area

Taking advantage of the extensive technical amenability of the fission yeast schizosaccharomyces pombe, our research group employs multi-disciplinary approaches, such as genetics , cell biology and molecular biology, to dissect the detailed mechanisms how the positive and negative regulators control faithful chromosome segregation, cell polar growth and heterochromatin formation in eukaryotes.
Major interests of our ongoing research focus on: (1) the molecular mechanisms coordinating timely spindle assembly checkpoint (SAC) silencing with chromosome segregation fidelity at anaphase; (2) the molecular mechanisms coordinating cell cycle with cell polar growth; (3) the molecular mechanisms involved in the epigenetic regulation of heterochromatin formation.

Selected Publications

1.Sun L^#, Liu L^#, Song C^#, Wang Y^*, Jin QW^*. (2024) Heat stress-induced activation of MAPK pathway attenuates Atf1-dependent epigenetic inheritance of heterochromatin in fission yeast. eLife, 13: e90525.
2.Wang X^#, Zheng F^#, Yi YY, Wang GY, Hong LX, McCollum D, Fu C^*, Wang Y^*, Jin QW^*. (2022) Ubiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress. Nature Communications. 13(1):5565.
3.Bai S^#, Sun L^#, Wang X, Wang SM, Luo ZQ, Wang Y^*, Jin QW^*. (2022) Recovery from spindle checkpoint-mediated arrest requires a novel Dnt1-dependent APC/C activation mechanism. PLoS Genetics. 18(9):e1010397.
4.Deng DJ^#, Wang X^#, Yue KY, Wang Y^*, Jin QW^*. (2022) Analysis of the potential role of fission yeast PP2A in spindle assembly checkpoint inactivation. FASEB Journal. 36(9):e22524.
5.Deng DJ^#, Xia QC^#, Jia GS^#, Suo F^#, Chen JL, Sun L, Wang JQ, Wang SM, Du LL, Wang Y^*, Jin QW^*. (2021) Perturbation of kinetochore function using GFP-binding protein in fission yeast. G3 Genes|Genomes|Genetics, jkab290.
6.Sun L, Liu XM, Li WZ, Yi YY, He X^*, Wang Y^*, Jin QW^*. (2020) The molecular chaperone Hsp90 regulates heterochromatin assembly through stabilizing multiple complexes in fission yeast. Journal of Cell Science. 133(13):jcs244863.
7.Bohnert KA, Rossi AM, Jin QW, Chen JS, Gould KL^*. (2020) Phosphoregulation of the cytokinetic protein Fic1 contributes to fission yeast growth polarity establishment. Journal of Cell Science. 133(18):jcs244392.
8.Zheng S, Dong F, Rasul F, Yao X, Jin QW, Zheng F, Fu C^*. (2018) Septins regulate the equatorial dynamics of the separation initiation network kinase Sid2p and glucan synthases to ensure proper cytokinesis. FEBS Journal. 285(13):2468-2480.
9.Qiu C^#, Yi YY^#, Lucena R, Wu MJ, Sun JH, Wang X, Jin QW^*, Wang Y^*. (2018) F-box proteins Pof3 and Pof1 regulate Wee1 degradation and mitotic entry in fission yeast. Journal of Cell Science. 131(3):jcs202895.
10.Chen YH, Wang GY, Hao HC, Chao CJ, Wang Y^*, Jin QW^*. (2017) Facile manipulation of protein localization in fission yeast through binding of GFP-binding protein to GFP. Journal of Cell Science. 130(5):1003-1015.
11.Chen YH^#, Chen LH^#, An K^#, Wang Y^*, Jin QW^*. (2015) A vector system for efficient and economical switching of a ura4+ module to three commonly used antibiotic marker cassettes in Schizosaccharomyces pombe. Yeast. 32(11):671-82.
12.Yu ZY, Zhang MT, Wang GY, Xu D, Keifenheim D, Franco A, Cansado J, Masuda H, Rhind N, Wang Y, Jin QW^*. (2013) Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase. Journal of Cell Science. 126(Pt 21):4995-5004.
13.Cipak L, Gupta S, Rajovic I, Jin QW, Anrather D, Ammerer G, McCollum D, Gregan J^*. (2013) Crosstalk between casein kinase II and Ste20-related kinase Nak1. Cell Cycle. 12(6):884-888.
14.Wang Y, Li WZ, Johnson AE, Luo ZQ, Sun XL, Feoktistova A, McDonald WH, McLeod I, Yates JR 3rd, Gould KL, McCollum D^*, Jin QW^*. (2012) Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein Dma1 in fission yeast. Molecular Biology of the Cell. 23:3348-3356.
15.Li WZ, Yu ZY, Ma PF, Wang Y and Jin QW^*. (2010) A Novel Role of Dma1 in Regulating Forespore Membrane Assembly and Sporulation in Fission Yeast. Molecular Biology of the Cell. 21: 4349-4360.
16.Jin QW, Ray S, Choi SH and McCollum D^*. (2007) The nucleolar Net1/Cfi1-related protein Dnt1 antagonizes the septation initiation network in fission yeast. Molecular Biology of the Cell. 18: 2924-2934.
17.Jin QW, Zhou M, Bimbo A, Balasubramanian MK and McCollum D^*. (2006) A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-250 suppressors. Genetics. 172: 2101-2112.
18.Jin QW and McCollum D^*. (2003) Scw1p antagonizes the septation initiation network to regulate septum formation and cell separation in the fission yeast Schizosaccharomyces pombe. Eukaryotic Cell. 2: 510-520.
19.Jin QW, Pidoux AL, Decker C, Allshire RC and Fleig U^*. (2002) The mal2p protein is an essential component of the fission yeast centromere. Molecular and Cellular Biology. 22: 7168-7183.
20.Davis L, Barbera M, McDonnell A, McIntyre K, Sternglanz R, Jin QW, Loidl J and Engebrecht J^*. (2001) The Saccharomyces cerevisiaeMUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks. Genetics. 157:1179-1189.
21.Jin QW, Fuchs J and Loidl J^*. (2000) Rabl-like chromosome arrangement is a major determinant of yeast interphase nuclear organization. Journal of Cell Science. 113:1903-1912.
22.Jin QW, Trelles-Sticken E, Scherthan H and Loidl J^*. (1998) Yeast nuclei display prominent centromere clustering that is reduced in nondividing cells and in meiotic prophase. Journal of Cell Biology. 141: 21-29.
23.Loidl J^*, Jin QW and Jantsch M. (1998) Meiotic pairing and segregation of translocation quadrivalents in yeast. Chromosoma. 107: 247-254.