 | Hangzi Chen, Ph.D. Professor E-mail: chenhz@xmu.edu.cn |
Education
1999-2003, School of Life Sciences, Xiamen University, Bachelor
2003-2009, School of Life Sciences, Xiamen University, Ph.D.
Professional Experience
2005, Department of Biological Sciences, National University of Singapore, Visiting Students
2009-2012, School of Life Sciences, Xiamen University, Assistant Professor
2012-2018, School of Life Sciences, Xiamen University, Associate Professor
2018-present, School of Life Sciences, Xiamen University, Professor
Research Area
The main interest of our lab is the understanding of metabolic regulation and cell fate determination of tumor cells, focusing on the process of sensing and adaptation of tumor cells to metabolic stress, and analyzing the role of nuclear receptor and other key node proteins in signal transduction and microenvironment remodeling.
Selected Publications (*Corresponding author, #co-first author)
1. Chen QT#, Zhang ZY#, Huang QL#, Chen HZ#*, Hong WB, Lin T, Zhao WX, Wang XM, Ju CY, Wu LZ, Huang YY, Hou PP, Wang WJ, Zhou D, Deng X, Wu Q*. HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma. Nature Metabolism. 2022;4(10):1306-1321.
2. Zhang JY#, Zhou B#, Sun RY#, Ai YL#, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ*, Qiao Wu*. The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. Cell Research. 2021 Sep;31(9):980-997.
3. Hou PP, Chen HZ*. Extracellular vesicles in the tumor immune microenvironment. Cancer Letters. 2021, 28;516:48-56.
4. Yang PB#, Hou PP#, Liu FY#, Hong WB#, Chen HZ#, Sun XY, Li P, Zhang Y, Ju CY, Luo LJ, Wu SF, Wang ZJ, He JP, Li L, Zhao TJ, Deng X, Lin T*, Wu Q*. Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression. Proc Natl Acad Sci U S A. 2020， 117(44):27412-27422.
5. Hou PP#, Luo LJ#, Chen HZ#, Chen QT#, Bian XL#, Wu SF, Zhou JX, Zhao WX, Liu JM, Wang XM, Zhang ZY, Yao LM, Chen QH, Zhou DW, Wu Q*. Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment. Molecular Cell. 2020，78(6):1192-1206.
6. Guan YF#, Huang QL#, Ai YL, Chen QT, Zhao WX, Wang XM, Wu Q, Chen HZ*. Nur77-activated lncRNA WFDC21P Attenuates Hepatocarcinogenesis via Modulating Glycolysis. Oncogene. 2020, 39 (11), 2408-2423.
7. Zhou B#, Zhang JY#, Liu XS#, Chen HZ#, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q*. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Research. 2018, 28(12):1171-1185.
8. He JP#, Hou PP#, Chen QT#, Wang WJ, Sun XY, Yang PB, Li YP, Yao LM, Li X, Jiang XD, Chien KY, Zhang ZM, Wu QW, Cowin AJ, Wu Q, Chen HZ*. Flightless-I Blocks p62-Mediated Recognition of LC3 to Impede Selective Autophagy and Promote Breast Cancer Progression. Cancer Research. 2018, 78(17):4853-4864.
9. Li XX#, Wang ZJ#, Zheng Y#, Guan YF#, Yang PB, Chen X, Peng C, He JP, Ai YL, Wu SF, Chien KY, Wu Q*, Chen HZ*. Nuclear receptor Nur77 facilitates melanoma cell survival under metabolic stress by protecting fatty acid oxidation. Molecular Cell. 2018, 69(3):480-492.
10. Bian XL#, Chen HZ#, Yang PB#, Li YP#, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q*. Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nature Communications. 2017.8:14420
11. Li L#, Liu Y#, Chen HZ#, Li FW#, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T*, Wu Q*. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nature Chemical Biology. 2015, 11(5):339-46.
