Education

1993, B.Sc., Nanchang University;

2001, Ph.D., Xiamen University.

Professional Experience

1993-1996, Assistant, Jiangxi Medical College;

2001-2003, Assistant Professor, Xiamen University;

2006-2008, Research Scholar, Department of Molecular and Cell Biology, University of California, Berkeley, USA;

2003-2010, Associate Professor, School of Life Sciences, Xiamen University;

2010-Present, Professor, School of Life Sciences, Xiamen University.

Research Area

Tumor metastasis involves dissemination of cancer cells to distant organ sites and their subsequent adaptation to and remodeling foreign tissue microenvironments. We have discovered that matricellular proteins (Periostin, OPN, etc) contribute to cell survival, EMT, stemness maintenance and angiogenesis during tumor metastasis. Our current work demonstrated that matricellular proteins play a critical role in remodeling tissue microenvironments during inflammation and tumor progression. We will continue to investigate the functions of matricellular proteins in stem cell niches and in inflammatory and metastatic microenvironments.

Selected Publications

1.Xiao H, Zhang Y, Li Z, Liu B, Cui D, Liu F, Chen D^*, Liu Y^*, Ouyang G^*. Periostin deficiency reduces diethylnitrosamine-induced liver cancer in mice by decreasing hepatic stellate cell activation and cancer cell proliferation. J Pathol, 2021; 255(2): 212-223.
2.Ma H, Wang J, Zhao X, Wu T, Huang Z, Chen D, Liu Y^*, Ouyang G^*. Periostin promotes colorectal tumorigenesis through integrin-FAK-Src pathway-mediated YAP/TAZ activation. Cell Rep, 2020; 30(3): 793-806.e6.
3.Ma Z, Zhao X, Deng M, Huang Z, Wang J, Wu Y, Cui D, Liu Y, Liu R^*, Ouyang G^*. Bone marrow mesenchymal stromal cell-derived periostin promotes B-ALL progression by modulating CCL2 in leukemia cells. Cell Rep, 2019; 26(6): 1533-1543.e4.
4.Wu T, Huang J, Wu S, Huang Z, Chen X, Liu Y, Cui D, Song G, Luo Q, Liu F^*, Ouyang G^*. Deficiency of periostin impairs liver regeneration in mice after partial hepatectomy. Matrix Biol, 2018; 66: 81-92.
5.Ma Z, Zhao X, Huang J, Jia X, Deng M, Cui D, Du Z, Fu G^*, Ouyang G^*, Xiao C^*. A critical role of periostin in B-cell acute lymphoblastic leukemia. Leukemia, 2017; 31(8): 1835-1837.
6.Wang Z, Xiong S, Mao Y, Chen M, Ma X, Zhou X, Ma Z, Liu F, Huang Z, Luo Q, Ouyang G^*. Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis. J Pathol, 2016; 239(4): 484-495.
7.Li Y, Wu S, Xiong S, Ouyang G^*. Deficiency of periostin protects mice against methionine-choline-deficient diet-induced nonalcoholic steatohepatitis. J Hepatol, 2015; 62(2): 495-497.
8.Wu T, Luo Q^*, Ouyang G^*. Periostin: a potent chemotactic factor for recruiting tumor-associated macrophage. Protein Cell, 2015; 6(4): 235-237.
9.Wu T, Wu S, Ouyang G^*. Periostin: a new extracellular regulator of obesity-induced hepatosteatosis. Cell Metab, 2014; 20(4): 562-564. (Preview)
10.Liu AY, Zheng H, Ouyang G^*. Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments. Matrix Biol, 2014; 37: 150-156.
11.Wu T, Ouyang G^*. Matricellular proteins: multifaceted extracellular regulators in tumor dormancy. Protein Cell, 2014; 5: 249-252.
12.Liu AY, Ouyang G^*. Tumor angiogenesis: glioblastoma stem cells as a new source of pericytes. Curr Biol, 2013; 23(13): R565-R568.
13.Wang Z, Ouyang G^*. Periostin: a bridge between cancer stem cells and their metastatic niche. Cell Stem Cell, 2012; 10(2): 111-112. (Preview)
14.Fang X, Cai Y, Liu J, Wang Z, Wu Q, Zhang Z, Yang CJ, Yuan L, Ouyang G^*. Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal. Oncogene, 2011; 30(47): 4707-4720.
15.Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, Shao R, Anderson RM, Rich JN, Wang XF^*. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell, 2004; 5(4): 329-339.