Education
2004, B.Sc., Shandong Normal University
2011, Ph.D., Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Professional Experience
2011-2013, Research Assistant, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
2013-2019, Visiting Fellow, National Institute of Allergy and Infectious Diseases, National Institutes of Health
2019-present, Principal Investigator of Mucosal Immunology Group, School of Life Sciences, Xiamen University
Research Area
The mammalian gut is colonized with trillions of micro-organisms termed the “microbiota”, which not only help their host with nutrient absorption, but also are intimately involved in various aspects of host physiology and pathology, including nervous system development, immune function and diseases, as well as tumorigenesis and the response to cancer therapy. Given the complexity and diversity of the microbiota, mammalian hosts have evolved a complex immune system that continuously interact with microbiota to maintain the physiological stability and local tissue homeostasis. We will combine traditional immune measurement such as flow cytometry with modern genomic technologies and especially highly multiplexes, quantitative immunohistochemistry to advance our understanding of the interaction between gut microbiota and host immune system and to discover new targets for establishment of gut homeostasis and treatment of bowel diseases.
Selected Publications (# co-first author, * corresponding author）
1.Huang, Y.#*, Mao, K.#*, and Germain, R. N. (2018) Thinking differently about ILCs-Not just tissue resident and not just the same as CD4(+) T-cell effectors. Immunol Rev 286, 160-171
2.Mao, K.*, Baptista, A. P., Tamoutounour, S., Zhuang, L., Bouladoux, N., Martins, A. J., Huang, Y., Gerner, M. Y., Belkaid, Y., and Germain, R. N.* (2018) Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism. Nature 554, 255-259
3.Huang, Y.*#, Mao, K. #, Chen, X., Sun, M. A., Kawabe, T., Li, W., Usher, N., Zhu, J., Urban, J. F., Jr., Paul, W. E., and Germain, R. N.* (2018) S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense. Science 359, 114-119
4.Mao, K. #, Chen, S. #, Chen, M., Ma, Y., Wang, Y., Huang, B., He, Z., Zeng, Y., Hu, Y., Sun, S., Li, J., Wu, X., Wang, X., Strober, W., Chen, C.*, Meng, G.*, and Sun, B*. (2013) Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res 23, 201-212
5.Mao, K. #, Chen, S. #, Wang, Y. #, Zeng, Y., Ma, Y., Hu, Y., Zhang, H., Sun, S., Wu, X., Meng, G., Pei, G.*, and Sun, B*. (2015) beta-arrestin1 is critical for the full activation of NLRP3 and NLRC4 inflammasomes. J Immunol 194, 1867-1873
6.Zhong, C., Cui, K., Wilhelm, C., Hu, G., Mao, K., Belkaid, Y., Zhao, K., and Zhu, J*. (2016) Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment. Nat Immunol 17, 169-178
7.Wang, Y., Yang, C., Mao, K., Chen, S., Meng, G.*, and Sun, B*. (2013) Cellular localization of NLRP3 inflammasome. Protein Cell 4, 425-431
8.Hu, Y. #, Mao, K. #, Zeng, Y., Chen, S., Tao, Z., Yang, C., Sun, S., Wu, X., Meng, G., and Sun, B*. (2010) Tripartite-motif protein 30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production. J Immunol 185, 7699-7705
9.Wang, Y., Mao, K., Sun, S., Lin, G., Wu, X., Yao, G., and Sun, B*. (2009) Trichosanthin functions as Th2-type adjuvant in induction of allergic airway inflammation. Cell Res 19, 962-972
10.Shi, M. #, Deng, W. #, Bi, E., Mao, K., Ji, Y., Lin, G., Wu, X., Tao, Z., Li, Z., Cai, X., Sun, S., Xiang, C.*, and Sun, B*. (2008) TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation. Nat Immunol 9, 369-377
