Education

2000-2004, B.Sc., School of Life Sciences, Nanchang University;

2005-2011, Ph.D., School of Life Sciences, Xiamen University;

2009-2011, Joint PhD student, National Institutes of Health, USA.

Professional Experience

2011-2019, Assistant professor, Xiamen University

2019-present, Associate professor, Xiamen University

Research Area

1. Molecular mechanism of virulence involved in Plasmodium-host interactions
2. Genetic basis of drug resistance in malaria parasite
3. Mechanisms that control the parasite development at different stages

Selected Publications

1.Xu R^#, Lin L^#, Jiao Z, Liang R, Guo Y, Zhang Y, Shang X, Wang Y, Wang X, Yao L, Liu S, Deng X, Yuan J^*, Su X-z^*, Li J^*: Deaggregation of mutant Plasmodium yoelii de-ubiquitinase UBP1 alters MDR1 localization to confer multidrug resistance. Nature Communications 2024, 15(1): 1774.
2.Liang R^#, Rao H^#, Pang Q, Xu R, Jiao Z, Lin L, Li L, Zhong L, Zhang Y, Guo Y, Xiao N, Liu S, Chen X-F^*, Su X-z^*, Li J^*: Human ApoE2 protects mice against Plasmodium berghei ANKA experimental cerebral malaria. mBio 2023, 14(6):e0234623.
3.Qian P^#, Wang X^#, Zhong C-Q^#, Wang J^#, Cai M, Nguitragoo W, Li J^*, Cui H^*, Yuan J^*: Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite. eLife 2022, 11: e77447.
4.Zhang C^#, Zhong T^#, Li Y^#, Li X^#, Yuan X, Liu L, Wu W, Wu J, Wu Y, Liang R, Xie X, Kang C, Liu Y, Lai Z, Xiao J, Tang Z, Jin R, Wang Y, Xiao Y, Zhang J, Li J^*, Liu Q^*, Sun Z^*, Zhong J^*: The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis. eLife 2021, 10: e70672.
5.Xu R, Liu Y, Fan R, Liang R, Yue L, Liu S, Su X-z^*, Li J^*: Generation and functional characterisation of Plasmodium yoelii csp deletion mutants using a microhomology-based CRISPR/Cas9 method. Int J Parasitol 2019, 49(9): 705-14.
6.Nair SC^#, Xu R^#, Pattaradilokrat S, Wu J, Qi Y, Zilversmit M, Ganesan S, Nagarajan V, Eastman RT, Orandle MS, Tan JC, Myers TG, Liu S, Long CA, Li J^*, Su X-z^*: A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence. Nature Communications 2017, 8(1): 223.
7.Su XZ^*, Li J. Artemisinin and malaria: Current understandings of drug activation, action, and resistance. Chin Sci Bull 2017, 62(18): 1928-1937.
8.Yu X^#, Cai B^#, Wang M, Tan P, Ding X, Wu J, Li J, Li Q, Liu P, Xing C, Wang HY, Su X-z^*, Wang R-F^*: Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality. Immunity 2016, 45(5): 1093-1107.
9.Li J^*, Cai B, Qi Y, Zhao W, Liu J, Xu R, Pang Q, Tao Z, Hong L, Liu S, Leerkes M, Quiñones M, Su X-z^*: UTR introns, antisense RNA and differentially spliced transcripts between Plasmodium yoelii subspecies. Malar J 2016, 15: 30.
10.Qi Y, Zhu F, Eastman RT, Fu Y, Zilversmit M, Pattaradilokrat S, Hong L, Liu S, McCutchan TF, Pan W, Xu W, Li J^*, Huang F^*, Su X-z^*: Regulation of Plasmodium yoelii Oocyst Development by Strain- and Stage-Specific Small-Subunit rRNA. mBio 2015, 6(2): e00117-15.
11.Wu J, Tian L, Yu X, Pattaradilokrat S, Li J, Wang M, Yu W, Qi Y, Zeituni AE, Nair SC, Crampton SP, Orandle MS, Bolland SM, Qi CF, Long CA, Myers TG, Coligan JE, Wang R^*, Su X-z^*: Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality. PNAS 2014, 111(4): E511-E520.
12.Li J, Yuan J, Chen CC, Inglese J, Su X-z^*: Chemical genomics for studying parasite gene function and interaction. Trends in Parasitol 2013, 29(12): 603-611.
13.Li J^#, Pattaradilokrat S^#, Zhu F^#, Jiang H, Liu S, Hong L, Fu Y, Koo L, Xu W, Pan W, Carlton JM, Kaneko O, Carter R, Wootton JC, Su X-z^*: Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii. PNAS 2011, 108(31): E374-E382.
14.Li J, Zhang Y, Liu S, Hong L, Sullivan M, McCutchan TF, Carlton JM, Su X-z^*: Hundreds of microsatellites for genotyping Plasmodium yoelii parasites. Mol Biochem Parasit 2009, 166(2): 153-158.
15.Li J, Zhang Y, Sullivan M, Hong L, Huang L, Lu F, McCutchan TF, Su X-z^*: Typing Plasmodium yoelii microsatellites using a simple and affordable fluorescent labeling method. Mol Biochem Parasit 2007, 155(2): 94-102.