| Chengyong He, Ph.D. Associate Professor Tel: +86-592-2187353 Email: hecy@xmu.edu.cn |
Education
2009.9-2012.12 PhD candidate, School of Life Sciences, Xiamen University,
2011.9-2012.8 Joint Cultivate PhD candidate, Molecular and Environmental Toxicology Center, University of Wisconsin-Madison
2007.9-2009.6 Graduated student, School of Life sciences, Xiamen University
Professional Experience
2013-2018 Assistant Professor-Associate Professor, School of Public Health, Xiamen University
2018-present Associate Professor, School of Life sciences, Xiamen University
Research Area
Environmental Toxicology
Nanotoxicology
Environmental Health
Selected Publications
10篇代表性科研论文（ #第一作者； *通讯作者）：
1. Naying Zheng, Tingting Liao, Chuchu Zhang, Zheyang Zhang, Sen Yan, Xiaohan Xi, Fengkai Ruan, Chunyan Yang, Qingliang Zhao, Wenbo Deng, Jialiang Huang, Zi-Tao Huang, Zhi-Feng Chen, Xiang Wang, Qingming Qu, Zhenghong Zuo *, Chengyong He *. Quantum Dots-caused Retinal Degeneration in Zebrafish Regulated by Ferroptosis and Mitophagy in Retinal Pigment Epithelial Cells through Inhibiting Spliceosome. Advanced Science. 2024:e2406343.
2. Fengkai Ruan, Jie Zeng, Changqian Liu, Jianrong Han, Naying Zheng, Kun Li, Hanying Yin, Mingtao Wu, Xiaoyan Ding, Changshun Han, Dai Wang, Lingtao Yang, Chunyan Yang, Nengming Xiao, Zhenghong Zuo *, Chengyong He *. Gut microbiota dysbiosis mediates mouse kidney fibrosis induced by black phosphorus quantum dots. Nano Today. 2024;55:102203.
3. Chengyong He # *, Fengkai Ruan #, Shengwei Jiang #, Jie Zeng, Hanying Yin, Rong Liu, Yongxing Zhang, Laiqiang Huang, Chonggang Wang, Shaohua Ma *, Zhenghong Zuo *. Black Phosphorus Quantum Dots Cause Nephrotoxicity in Organoids, Mice and Human Cells. Small. 2020;2001371.
4. Haoxing Cai, Mingyue Chen, Yang Gao, Jinpeng Ruan, Chengyong He *, and Zhenghong Zuo *. Transgenerational Effects and Mechanisms of Tributyltin Exposure on Neurodevelopment in the Male Offspring of Rats. Environmental Science & Technology. 2023;57:10201-10210.
5. Ruan #, Jie Zeng #, Hanying Yin #, Shengwei Jiang, Xisen Cao, Naying Zheng, Changshun Han, Chuchu Zhang, Zhenghong Zuo *, Chengyong He *. RNA m6A Modification Alteration by Black Phosphorus Quantum Dots Regulates Cell Ferroptosis: Implications for Nanotoxicological Assessment. Small Methods. 2021;5(3):e2001045.
6. Mingyue Chen #, Chengyong He #, Kongyang Zhu, Zihan Chen, Zixiao Meng, Xiaoming Jiang, Jiali Cai, Chunyan Yang, Zhenghong Zuo *. Resveratrol ameliorates polycystic ovary syndrome via transzonal projections within oocyte-granulosa cell communication. Theranostics. 2022;12(2):782-795. (Cover Story)
7. Fengkai Ruan, Rong Liu, Jie Zeng, Kai Wang, Zhenghong Zuo, Chengyong He *, Yongxing Zhang *. Cytotoxicity of black phosphorus quantum dots on lung-derived cells and the underlying mechanisms. Journal of Hazardous Materials. 2021;402:122875.
8. Fengkai Ruan, Changqian Liu, Yi Wang, Xisen Cao, Zhen Tang, Jiaying Xu, Jie Zeng, Hanying Yin, Naying Zheng, Chunyan Yang, Zhenghong Zuo, Chengyong He *. Role of RNA m6A modification in titanium dioxide nanoparticle-induced acute pulmonary injury: An in vitro and in vivo study. Environmental Pollution. 2022;311:119986.
9. Naying Zheng #, Xiaolian Sun #, Yiyue Shi #, Luheng Chen, Luanjin Wang, Haoxing Cai, Changshun Han, Tingting Liao, Chunyan Yang, Zhenghong Zuo, Chengyong He *. The valence state of iron-based nanomaterials determines the ferroptosis potential in a zebrafish model. Science of The Total Environment. 2023:855:158715.
10. Fengkai Ruan, Changqian Liu, Jie Zeng, Fucong Zhang, Yu Jiang, Zhenghong Zuo, Chengyong He *. Multi-omics integration identifies ferroptosis involved in black phosphorus quantum dots-induced renal injury. Science of the Total Environment. 2024;947:174532.
其他一作/通讯论文：
2024
11. Changqian Liu, Fengkai Ruan, Zhiyuan Chen, Jianrong Han, Xiaoyan Ding, Changshun Han, Lingxiao Ye, Chunyan Yang, Yi Yu, Zhenghong Zuo, Chengyong He *. Phenanthrene-induced hyperuricemia with intestinal barrier damage and the protective role of theabrownin: modulation by gut microbiota-mediated bile acid metabolism. Science of the Total Environment. 2024;949:174923.
12. Luanjin Wang, Cixin Liang, Naying Zheng, Chunyan Yang, Sen Yan, Xiang Wang, Zhenghong Zuo, Chengyong He *. Kidney injury contributes to edema of zebrafish larvae caused by quantum dots. Science of The Total Environment. 2024;908:168420.
13. Changshun Han #, Chengyong He #, Xiaoyan Ding, Zixuan Li, Tianyun Peng, Chensong Zhang, Haibing Chen, Zhenghong Zuo, Jiyi Huang *, and Weiping Hu *. WWC1 upregulation accelerates hyperuricemia by reduction in renal uric acid excretion through Hippo signaling pathway. Journal of Biological Chemistry. 2024;300(8):107485.
14. Jianrong Han, Fengkai Ruan, Chunyan Yang, Zhenghong Zuo, Zonghong Liu *, Chengyong He *. Subacute exposure to black phosphorus quantum dots induces cardiac fibrosis and the potential role of gut microbiota. Journal of Environmental Sciences. 2024. https://doi.org/10.1016/j.jes.2024.03.049.
15. Shuo Huang, Jingyi Wang, Tingting Lin, Chengyong He *, Zhiyuan Chen *. Esketamine Exposure Impairs Cardiac Development and Function in Zebrafish Larvae. Toxics. 2024;12(6):427.
2023
16. Tingting Lin, Li Zhou, Zhibin Chen, Luanjin Wang, Jian Yang, Sheng Wang, Xintan Chen, Zhenghong Zuo, Chengyong He *, Lanping Guo *. Exposure to echimidine impairs the heart development and function of zebrafish larvae. Ecotoxicology and Environmental Safety. 2023;266:115574.
17. Meifang Wu #, Naying Zheng #, Xiaoxiao Zhan, Jianzhang He, Min Xiao, Zhenghong Zuo, Chengyong He *. Icariin induces developmental toxicity via thyroid hormone disruption in zebrafish larvae. Food and Chemical Toxicology. 2023;182:114155.
18. Hanying Yin, You Gao, Weiguang Chen, Chen Tang, Zihan Zhu, Kun Li, Siyu Xia, Changshun Han, Xiaoyan Ding, Fengkai Ruan, Hanrui Tian, Changfeng Zhu, Suyuan Xie, Zhenghong Zuo, Lixin Liao *, Chengyong He *. Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species. Discover Nano. 2023;18(1):101.
2022
19. Jie Zeng, Fengkai Ruan, Mingtao Wu, Jiaying Xu, Zhenghong Zuo, Yi Yu *, Chengyong He *. Black phosphorus quantum dots cause glucose metabolism disorder and insulin resistance in mice. Ecotoxicology and Environmental Safety. 2022;246:114168.
20. Songwen Ren #, You Gao #, Luanjin Wang, Ce Qiu, Lingtao Yang, Li Li, Yueyue Xiao, Nengming Xiao, Lixin Liao, Zhenghong Zuo, Chunyan Yang *, Chengyong He *. Sacran polysaccharide improves atopic dermatitis through inhibiting Th2 type immune response. Life Sciences. 2022;288:120205.
21. Yi Wang, Fengkai Ruan, Zhenghong Zuo, Chengyong He *. Nanoparticle-Induced m6A RNA Modification: Detection Methods, Mechanisms and Applications. Nanomaterials. 2022;12(3): 389.
2021
22. Naying Zheng, Jinhui Yan, Wang Qian, Chao Song, Zhenghong Zuo, Chengyong He *. Comparison of developmental toxicity of different surface modified CdSe/ZnS QDs in zebrafish embryos. Journal of Environmental Sciences. 2021;100:240-249.
23. Junxia Shi, Chenyu Liu, Mingyue Chen, Jinhui Yan, Chonggang Wang, Zhenghong Zuo *, Chengyong He *. The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells. Environmental Toxicology. 2021;36(4):665-674.
24. Kongyang Zhu #, Chao Shen #, Chen Tang, Yixi Zhou, Chengyong He *, Zhenghong Zuo *. Improvement in the screening performance of potential aryl hydrocarbon receptor ligands by using supervised machine learning. Chemosphere. 2021;265:129099.
25. Yixi Zhou, Xue Han, Yuanyuan Bao, Zihan Zhu, Jiali Huang, Chunyan Yang, Chengyong He *, Zhenghong Zuo *. Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma). Aquatic Toxicology. 2021;238:105917.
2020
26. Chen Tang, Chao Shen, Kongyang Zhu, Yixi Zhou, Yung-Jen Chuang, Chengyong He *, Zhenghong Zuo *. Exposure to the AhR agonist cyprodinil impacts the cardiac development and function of zebrafish larvae. Ecotoxicology and Environmental Safety. 2020;201:110808.
27. Jinhui Yan, Shujing Chen, Zhenghong Zuo, Chengyong He *, Muqing Yi *. Graphene oxide quantum dot exposure induces abnormalities in locomotor activities and mechanisms in zebrafish (Danio rerio). Journal of Applied Toxicology. 2020;40:794–803.
2019
28. Chuanli Yang, Peiyu Han, Fengkai Ruan, Tengjian Zhou, Bing Luo, Yang Qiu, Yuchun Lin, Zhongning Lin *, Chengyong He *. Lactational exposure to environmentally relevant benzo(a)pyrene causes astrocytic activation and anxiety-like behavior in male mice. Chemosphere. 2019;221: 67e74.
29. Zhibing Yang, Junxia Shi, Zhizhun Guo, Mingyue Chen, Chonggang Wang, Chengyong He *, Zhenghong Zuo *. A pilot study on polycystic ovarian syndrome caused by neonatal exposure to tributyltin and bisphenol A in rats. Chemosphere. 2019;231:151-160.
30. Chengyong He #, Shengwei Jiang #, Huan Yao #, Liyin Zhang, Chuanli Yang, Shan Jiang, Fengkai Ruan, Denglin Zhan, Gang Liu, Zhongning Lin *, Yuchun Lin *, Xiaoyuan Chen. High-content analysis for mitophagy response to nanoparticles: A potential sensitive biomarker for nanosafety assessment. Nanomedicine-Nanotechnology Biology and Medicine. 2019;15(1):59-69.
2018及以前
31. Shengwei Jiang #, Yuchun Lin #, Huan Yao #, Chuanli Yang, Liyin Zhang, Bing Luo, Zhao Lei, Liwei Cao, Naibo Lin, Xiangyang Liu *, Zhongning Lin *, Chengyong He *. The role of unfolded protein response and ER-phagy in quantum dots-induced nephrotoxicity: an in vitro and in vivo study. Archives of Toxicology. 2018;92(541):1-14.
32. Chengyong He #, Yang Qiu #, Peiyu Han #, Yuanyuan Chen, Liyin Zhang, Quan Yuan, Tianying Zhang, Tong Cheng, Lunzhi Yuan, Chenghao Huang, Sheng Zhang, Zhenyu Yin, Xian-E Peng, Dong Liang, Xu Lin, Yuchun Lin *, Zhongning Lin *, and Ningshao Xia. ER stress regulating protein phosphatase 2A-B56γ, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes. Cell Death & Disease. 2018;9(7):762.
33. Chengyong He #, Shengwei Jiang #, Huan Yao #, Liyin Zhang, Chuanli Yang, Denglin Zhan, Gan Lin, Yun Zeng, Yankai Xia, Zhongning Lin *, Gang Liu *, Yuchun Lin *. Endoplasmic reticulum stress mediates inflammatory response triggered by ultra-small superparamagnetic iron oxide nanoparticles in hepatocytes. Nanotoxicology. 2018;12(10): 1198-1214.
34. Mei Chen #, Shuzhen Chen #, Chengyong He #, Shiguang Mo, Xiaoyong Wang, Gang Liu *, and Nanfeng Zheng *, Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging. Nano Research. 2017;10(4): 1234–1248.
35. Chengyong He #, Shengwei Jiang #, Haijing Jin #, Shuzhen Chen, Gan Lin, Huan Yao, Xiaoyong Wang, Peng Mi, Zhiliang Ji, Yuchun Lin *, Zhongning Lin *, Gang Liu *. Mitochondrial electron transport chain identified as a novel molecular target of SPIO nanoparticles mediated cancer-specific cytotoxicity. Biomaterials. 2016;83:102-114.
36. Bing Luo #, Yuchun Lin #, Shengwei Jiang, Lianyun Huang, Huan Yao, Qunying Zhuang, Ran Zhao, Hengchuan Liu, Chengyong He *, Zhongning Lin *. Endoplasmic reticulum stress eIF2α-ATF4 pathway-mediated cyclooxygenase-2 induction regulates cadmium-induced autophagy in kidney. Cell Death & Disease. 2016;7:e2251.
37. Chengyong He, Zhenghong Zuo, Xiao Shi, Lingbin Sun, Chonggang Wang *, Pyrene exposure influences the thyroid development of Sebastiscus marmoratus embryos. Aquatic Toxicology. 2012:124-125C;28-33.
38. Chengyong He, Chonggang Wang, Bowen Li, Meifang Wu, Hong Geng, Yixin Chen, Zhenghong Zuo *. Exposure of Sebastiscus marmoratus embryos to pyrene results in neurodevelopmental defects and disturbs related mechanisms. Aquatic Toxicology. 2012;116-117: 109-115.
39. Chengyong He, Zhenghong Zuo, Xiao Shi, Ruixia Li, Donglei Chen, Xin Huang, Yixin Chen, Chonggang Wang *. Effects of Benzo(a)Pyrene on the skeletal development of Sebastiscus marmoratus embryos and the molecular mechanism involved. Aquatic Toxicology. 2011;101:335–341.
40. Chengyong He, Chonggang Wang, Yulin Zhou, Jian Li, Zhenghong Zuo *. Embryonic exposure to benzo(a)pyrene influences neural development and function in rockfish (Sebastiscus marmoratus). Neurotoxicology. 2012; 33:758-762.
41. Chengyong He, Chonggang Wang, Bowen Li, Fazhi Xie, Yixin Chen, Zhenghong Zuo *. Tissue-specific and embryonic expression of the retinoid X receptors in Sebastiscus marmoratus. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2009; 154(2):221-228.
