Education

2006, B.Sc., School of Life Sciences, Xiamen University

2011, Ph.D., Shanghai Institution of Biochemistry and Cell Biology, CAS

Professional Experience

2011-2018, Postdoctoral Fellow, School of Life Sciences, Xiamen University

2018-present, Associate Professor, School of Life Sciences, Xiamen University

Research Area

Cell death is a fundamental feature of life and functions in many important biological processes including development, homeostasis and pathogenesis. We focuses on 1) molecular mechanisms that control cell necroptosis and pyroptosis; 2) functions of cell death in health and disease.Another goal ofour work is to take microscopy visualization (super-resolution imaging, particularly) as the primary approach to address problems of biomedical interest.

Selected Publications * Corresponding author  ^# Co-first author) 

1.Chen X^*, Zhu R, Zhong J, Ying Y, Wang W, Cao Y, Cai H, Li X, Shuai J, Han J^*. Mosaic composition of RIP1-RIP3 signalling hub and its role in regulating cell death. Nat Cell Biol. 2022 Apr;24(4):471-482.
2.Xue Z, Wang S, Li J, Chen X^*, Han J, Han S^*. Bifunctional Super-resolution Imaging Probe with Acidity-independent Lysosome-retention Mechanism. Anal Chem. 2018 Oct 2;90(19):11393-11400.
3.Chen X^#, He WT^#, Hu L, Li J, Fang Y, Wang X, Xu X, Wang Z, Huang K, Han J^*. Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis. Cell Res. 2016 Sep;26(9):1007-20.
4.Chen X^#, Li W^#, Ren J^#, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J^*. Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res. 2014 Jan;24(1):105-21. This article was highlighted by Cell Res, recommended by Faculty of 1000 Biology, and regarded as a highly cited paper by Web of Science.
5.Chen X^#, Ma JJ^#, Tan M, Yao P, Hu QH, Eriani G, Wang ED^*. Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase. Nucleic Acids Res. 2011 Jan;39(1):235-47.
6.Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q. Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis. Mol Cell. 2022 May 19;82(10):1821-1835.e6.
7.Zhou X^#, Ma F^#, Xie J^#, Yuan M^#, Li Y^#, Shaabani N^#, Zhao F, Huang D, Wu NC, Lee CD, Liu H, Li J, Chen Z, Hong Y, Liu WH, Xiao N, Burton DR, Tu H, Li H, Chen X, Teijaro JR, Wilson IA^*, Xiao C^*, Huang Z^*. Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2. Cell Rep. 2021 May 11;35(6):109109.
8.Li M^#, Zhang CS^#, Zong Y^#, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC^*. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK. Cell Metab. 2019;30(3):508-524.e12.
9.Gao H^#, Yang Z^#, Wang X^#, Qian P, Hong R, Chen X, Su XZ, Cui H, Yuan J^*. ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility. Curr Biol. 2018;28(17):2763–2776.e6.
10.Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J^*. RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis. Nat Cell Biol. 2018 Feb;20(2):186-197.
11.Zhang Y, Chen X, Gueydan C, Han J^*. Plasma membrane changes during programmed cell deaths. Cell Res. 2018 Jan;28(1):9-21.