Pingli Mo, Ph.D.                                           Associate Professor. Tel: 86-592-2182083 E-mail: mop@xmu.edu.cn

_Education

2006 Ph.D., Molecular Biology, Xiamen University, Fujian, China

2003 M. S., Biology, Guangxi University, Guangxi, China

2000 B. S., Biology, Guangxi University, Guangxi, China

_{Professional Experience}

2008-2010 Postdoctoral Research Associate，Center for Cell and Cancer Biology，Albany Medical College, Albany, NY 12208

2006-2007 Postdoctoral Research Associate, Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences, China

2011-present,Associate Professor, School of Life Sciences, Xiamen University

Research Area
Cancer is one of the diseases with the highest mortality rate in the world. Although there have been significant advances in the screening, diagnosis, and treatment of tumors in recent years, the mechanism of tumor formation is still not fully understood. Many studies have shown that the occurrence and development of cancers are related to abnormalities in multiple signaling pathways, such as WNT, NOTCH, p53, DNA damage repair, PI3K, etc. Therefore, our research interest mainly lies in revealing the role of these signaling pathways in the occurrence and development of tumors, and providing a theoretical basis for future targeted therapies for tumors.

Selected Publications)(^# co-first author, ^* Corresponding author

1.Guo P^*, Chen Q^*, Peng K^*, Xie J, Liu J, Ren W, Tong Z, Li M, Xu J, Zhang Y^#, Yu C^#, Mo P^#. Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling. Oncogene, 2022 May;41(20):2846-2859. (^#Co-corresponding author)
2.Chen Q, Peng K, Mo P^#, Yu C^#. Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers. Cancers (Basel) . 2022 Jun 8;14(12):2841 (^#Co-corresponding author)
3.Chen Q ^*, Hong Y^*, Weng S, Guo P, Li B, Zhang Y, Yu C^#, Wang S^# , Mo P^#. Traditional Chinese Medicine Pien-Tze-Huang Inhibits Colorectal Cancer Growth and Immune Evasion by Reducing β-catenin Transcriptional Activity and PD-L1 Expression. Front Pharmacol Published: 03 February 2022 doi: 10.3389/fphar.2022.828440 (^#Co-corresponding author)  
4.Peng K^*, Zhuo M^*, Li M, Chen Q, Mo P^#, Yu C^#. Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression. Oncogene. 2020 Nov; 39 (47):7076-7091. (^#Co-corresponding author)
5.Zhuo M^*, Chen W^*, Shang S, Guo P, Peng K, Li M, Mo P, Zhang Y, Qiu X, Li W, Yu C Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling. Oncogene. 2020 Apr; 39(16):3336-3353.
6.Li M, Wang Y, Xia X, Mo P, Xu J, Yu C, Li W.Steroid receptor coactivator 3 inhibits hepatitis B virus gene expression through activating Akt signaling to prevent HNF4α nuclear translocation. Cell Biosci. 2019 Aug 13; 9:64.
7.Deng Y^*, Li M^*, Zhuo M, Guo P, Chen Q, Mo P, Li W, Yu C.Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression. J Biol Chem. 2020 Nov 24; 296:100121.
8.Li M^*, Deng Y^*, Zhuo M, Zhou H, Kong X, Xia X, Su Z, Chen Q, Guo P, Mo P, Yu C, Li W. Demethylase-independent function of JMJD2D as a novel antagonist of p53 to promote Liver Cancer initiation and progression. Theranostics. 2020 Jul 11;10(19):8863-8879.
9.Li M, Wang Y, Xia X, Mo P, Xu J, Yu C, Li W.Steroid receptor coactivator 3 inhibits hepatitis B virus gene expression through activating Akt signaling to prevent HNF4α nuclear translocation. Cell Biosci. 2019 Aug 13;9:64.
10.Peng K, Kou L, Yu L, Bai C, Li M, Mo P, Li W, Yu C. Histone Demethylase JMJD2D Interacts With β-Catenin to Induce Transcription and Activate Colorectal Cancer Cell Proliferation and Tumor Growth in Mice. Gastroenterology. 2019 Mar;156(4):1112-1126.
11.Chen W^*, Mo P^*, Yu C. Roles of Steroid Receptor Coactivator 3 in Host Defense Against Bacterial Pathogens. Crit Rev Immunol. 2018;3 8(3):245-252(^* Equal contribution)
12.Peng K^*, Su G^*, Ji J, Yang X, Miao M, Mo P, Li M, Xu J, Li W, Yu C. Histone demethylase JMJD1A promotes colorectal cancer growth and metastasis by enhancing Wnt/β-catenin signaling. J Biol Chem. 2018 Jul 6; 293(27):10606-10619 (^* Equal contribution)
13.Mo P, Yang S.The store-operated calcium channels in cancer metastasis: from cell migration, invasion to metastatic colonization. Front Biosci (Landmark Ed) . 2018 Jan 1;23:1241-1256.
14.Chen W, Lu X, Chen Y, Li M, Mo P, Tong Z, Wang W, Wan W, Su G, Xu J, Yu C.Steroid Receptor Coactivator 3 Contributes to Host Defense against Enteric Bacteria by Recruiting Neutrophils via Upregulation of CXCL2 Expression. J Immunol. 2017 Feb 15; 198(4):1606-1615.
15.Majaz S^*, Tong Z^*, Peng K, Wang W, Ren W, Li M, Liu K, Mo P, Li W, Yu C. Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression. Cell Biosci. 2016 2; 6:47. doi: 10.1186/s13578-016-0114-6(^* Equal contribution)
16.Li M^*, Wang W^*, Dan Y, Tong Z, Chen W, Qin L, Liu K, Li W, Mo P^#, Yu C^#. Downregulation of amplified in breast cancer 1 contributes to the anti-tumor effects of sorafenib on human hepatocellular carcinoma.(^* Co-Corresponding Author). 2016 May17;7(20):29605-19 (^* Equal contribution, ^#Co-corresponding author)
17.Tong Z^*, Li M^*, Wang W, Mo P, Yu L, Liu K, Ren W, Li W, Zhang H, Xu J, Yu C. Steroid Receptor Coactivator 1 Promotes Human Hepatocellular Carcinoma Progression by Enhancing Wnt/β-Catenin Signaling. J Biol Chem. 2015 Jul 24; 290(30):18596-608 (^* Equal contribution)
18.Mo P^*, Zhou Q^*, Guan L^*, Wang Y, Wang W, Miao M, Tong Z, Li M, Majaz S, Liu Y, Su G, Xu J, Yu C. Amplified in breast cancer 1 promotes colorectal cancer progression through enhancing notch signaling. Oncogene. 2015 Jul 23;34(30):3935-45(^*Equal contribution)
19.Xia X, Wan W, Chen Q, Liu K, Majaz S, Mo P, Xu J, Yu C. Deficiency in steroid receptor coactivator 3 enhances cytokine production in IgE-stimulated mast cells and passive systemic anaphylaxis in mice. Cell Biosci. 2014 Apr 23; 4:21.
20.Xia XC, Chen Q, Liu K, Mo PL, Zhu JW, Zhuang MQ, Shen YM, Yu CD. Mycoepoxydiene inhibits antigen-stimulated activation of mast cells and suppresses IgE-mediated anaphylaxis in mice. Int Immunopharmacol. 2013 Oct;17(2):336-41
21.Zhu J, Chen Q, Xia X, Mo P, Shen Y, Yu C. Mycoepoxydiene suppresses RANKL-induced osteoclast differentiation and reduces ovariectomy-induced bone loss in mice. Appl Microbiol Biotechnol. 2013 Jan; 97(2):767-74
22.Mo P, Wang H, Lu H, Boyd D, Yan C. MDM2 mediates ubiquitination and degradation of activating transcription factor 3. J. Biol. Chem. 2010 285, 26908-26915
23.Wang H^*, Mo P^*, Ren S, Yan C. Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6. J. Biol. Chem. 2010 285: 13201-13210(^* Equal contribution)
24.Mo P, Zhu Y, Liu X, Wang D.  Identification of two phosphatidylinositol /phosphatidylcholine transfer proteins that are predominately transcribed in the flowers of Arabidopsis thaliana. Journal of Plant Physiology, 2007, 4: 478-486